Q1 Research Application · Frontier Focus

Synthesis of Ketones through Microwave Irradiation Promoted Metal-free Alkylation of Aldehydes by Activation of C(sp3)−H Bond

This Journal of Organic Chemistry paper (2015) is indexed as a Xianghu equipment application case for XH-200A / XH-200C; key result: Yield 62%.

View DOI Back to Library Chinese Solution
Paper ID 378
Application Focus C(sp³)-H, from
Key Result Yield 62%
Core Condition Temperature 180 °C
Paper ID
378
Journal
Journal of Organic Chemistry
Impact Factor
4.335
CAS Zone
Zone 1
Year
2015
DOI
10.1021/acs.joc.5b01824
Equipment Model
XH-200A / XH-200C
Affiliations
Henan Normal University; School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, China
Research Directions
C(sp³)-H from

Fact Snapshot

  • Paper: Synthesis of Ketones through Microwave Irradiation Promoted Metal-free Alkylation of Aldehydes by Activation of C(sp3)−H Bond
  • Equipment: XH-200A / XH-200C
  • Source: Journal of Organic Chemistry, 2015
  • Research direction: C(sp³)-H and from
  • Core conditions: Temperature 180 °C and Time 1 h / 24 h
  • Key results: Yield 62%, Similar efficiency -63%, Yield -66%, and Yield 55%

Research Abstract

Synthesis of Ketones through Microwave Irradiation Promoted Metal-free Alkylation of Aldehydes by Activation of C(sp3)−H Bond was published in Journal of Organic Chemistry (2015) and is indexed as a SoarNova / Xianghu Q1 application case for XH-200A / XH-200C. The source record connects it with C(sp³)-H and from. Core operating conditions include Temperature 180 °C and Time 1 h / 24 h. Key reported results include Yield 62%, Similar efficiency -63%, Yield -66%, and Yield 55%.

Research Background and Problem

The paper is positioned around C(sp³)-H and from. The equipment record identifies XH-200A / XH-200C as the Xianghu instrument context for this application case. The source affiliation record includes Henan Normal University and School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, China.

Equipment Use and Experimental Conditions

ItemParameter
Temperature180 °C
Time1 h / 24 h

Key Result

Yield 62%
Yield -66%
Yield 55%
Yield 58%
MetricResult
Yield62%
Yield-66%
Yield55%
Yield58%
Yield57%
Similar efficiency-63%

Evidence Details

Yield evidence

Yield evidence: source values include 140 °C, 5%, 180 °C, 1 h, 58%.

Yield evidence

Yield evidence: source values include 57%, 55%, 56%, 53%.

Yield evidence

Yield evidence: source values include 24 h, 1 h, 58%.

Composition evidence

Composition evidence: source values include 10 mL, 180 °C, 1 h.

Yield evidence

Yield evidence: source values include 41-66%, 36-48%.

Yield evidence

Yield evidence: source values include 62%, 55%.

Additional source evidence

Additional source evidence: source values include 120 °C, 24 h.

Structured key result

Similar efficiency: -63%

Structured key result

Yield: -66%

Additional source evidence

"MWI promoted reactions were performed in a commercial microwave reactor (XH-200A, Beijing Xianghu Science and Technology Development Co. Ltd, Beijing, China)."

Mechanism / Method Highlights

  • Method context: Temperature 180 °C and Time 1 h / 24 h.
  • Yield evidence: source values include 140 °C, 5%, 180 °C, 1 h, 58%
  • Yield evidence: source values include 57%, 55%, 56%, 53%
  • Yield evidence: source values include 24 h, 1 h, 58%
  • Reported outcome: Yield 62%, Similar efficiency -63%, Yield -66%, and Yield 55%.

Application Value

  • Provides a peer-reviewed SoarNova / Xianghu Q1 application case for XH-200A / XH-200C.
  • Supports English discovery around C(sp³)-H and from.
  • Preserves quantitative result evidence: Yield 62%, Similar efficiency -63%, Yield -66%, and Yield 55%.
  • Maintains source-level evidence details: Yield evidence: source values include 140 °C, 5%, 180 °C, 1 h, 58%, Yield evidence: source values include 57%, 55%, 56%, 53%, Yield evidence: source values include 24 h, 1 h, 58%, and Composition evidence: source values include 10 mL, 180 °C, 1 h.

Related Equipment

XH-200A+ Microwave Solid-Liquid Phase Synthesis/Extraction System
XH-200A+ Microwave Solid-Liquid Phase Synthesis/Extraction System

FAQ

Which Xianghu instrument is covered by this page?
The structured source records XH-200A / XH-200C for this paper.
What is the main application direction?
The source tags this paper under C(sp³)-H and from.
Which publication does this case come from?
It comes from Journal of Organic Chemistry (2015), DOI 10.1021/acs.joc.5b01824.
Citation
Synthesis of Ketones through Microwave Irradiation Promoted Metal-free Alkylation of Aldehydes by Activation of C(sp3)−H Bond
Journal of Organic Chemistry, 2015
DOI: 10.1021/acs.joc.5b01824